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DSIP Chemical
Human and animal studies

DSIP references show how small the human record is.

The full list covers sleep, hormones, aging mice, and the main review.

Plain study findingsHuman sleep results

The DSIP study list begins with animals and small human tests

Which studies support the DSIP claims? The list begins with rabbit work from 1977. It also includes small human sleep tests from the 1980s. Those human tests never grew into a large current trial.

The list also covers animal sleep and hormone work. Mouse aging work and the altered-peptide test from 2024 appear too. These studies cannot prove a benefit for you. They show what happened to animals or small groups of people.

A major review found the sleep proof weak. Later altered forms sometimes caused clearer changes than plain DSIP. Independent teams have not repeated several large mouse findings. The study names and links below let you check those limits.

  1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977;74(3):1282-1286. ↗
  2. Schneider-Helmert D, et al.. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia. 1981;37(8):913-914. ↗
  3. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. ↗
  4. Bjartell A, Ekman R, Bergquist S, Widerlov E. Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man. Psychoneuroendocrinology. 1989;14(5):347-355. ↗
  5. Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003;124(6):721-731. ↗
  6. Mu X, Qu L, Yin L, Wang L, Liu X, Liu D. Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. Front Pharmacol. 2024;15:1439536. ↗
  7. Schneider-Helmert D. Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia. Eur Neurol. 1987;27(2):120-129. ↗
  8. Schneider-Helmert D. The use of DSIP (delta sleep-inducing peptide) in the correction of phase-shifted insomnia. Dtsch Med Wochenschr. 1987;112(20):779-783. ↗
  9. Sudakov KV, et al.. The effect of delta sleep-inducing peptide on the EEG and power spectra in rat. Indian J Physiol Pharmacol. 2000;44(3):289-298. ↗
  10. Tobler I, Borbely AA. The effect of subcutaneous administration of delta sleep-inducing peptide (DSIP) on some parameters of sleep in the cat. Physiol Behav. 1987;39(2):245-248. ↗
  11. Schoenenberger GA. Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP). Eur Neurol. 1984;23(5):321-345. ↗
  12. Bjartell A, Castro MG, Ekman R, Sundler F, Widerlöv E, Loh YP. Immunoreactive delta sleep-inducing peptide secretion from mouse dissociated, anterior pituitary cells: regulation by corticotropin-releasing factor and arginine vasopressin. Neuroendocrinology. 1989;50:564-9. ↗
  13. Bjartell A, Ekman R, Hedenbro J, Sjölund K, Sundler F. Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones. Peptides. 1989;10:163-70. ↗
  14. Ahlman H, Ahlund L, Nilsson O, Dahlström A, Bjartell A, Ekman R. Coexistence of delta sleep-inducing peptide and serotonin in midgut carcinoid tumour cells in vivo and in vitro. International journal of cancer. 1989;44:641-7. ↗
  15. Lesch KP, Widerlöv E, Ekman R, Laux G, Schulte HM, Pfüller H, Beckmann H. Delta sleep-inducing peptide response to human corticotropin-releasing hormone (CRH) in major depressive disorder. Comparison with CRH-induced corticotropin and cortisol secretion. Biological psychiatry. 1988;24:162-72. ↗