A data-forward digest of the delta sleep-inducing peptide — what the EEG, sleep-architecture, and neuroendocrine literature actually measured, and where the evidence stays thin.
DSIP Chemical

The literature

DSIP references: every source behind the numbers.

The cited studies, with PubMed links and DOIs where available.

Back to the researchDSIP for sleep

About these DSIP references

Every quantitative claim across this site maps to one of the DSIP references listed below — the founding 1977 EEG isolation, the small 1980s human sleep trials, the animal EEG and neuroendocrine work, the Deltaran longevity data, and the 2024 fusion-peptide study. Each entry includes the journal, year, and a PubMed link, with a DOI where one is published. Where a finding rests on weak or unreplicated evidence, the relevant page says so. The full citation list renders below.

  1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977;74(3):1282-1286. ↗
  2. Schneider-Helmert D, et al.. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia. 1981;37(8):913-914. ↗
  3. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. ↗
  4. Bjartell A, Ekman R, Bergquist S, Widerlov E. Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man. Psychoneuroendocrinology. 1989;14(5):347-355. ↗
  5. Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003;124(6):721-731. ↗
  6. Mu X, Qu L, Yin L, Wang L, Liu X, Liu D. Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. Front Pharmacol. 2024;15:1439536. ↗
  7. Schneider-Helmert D. Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia. Eur Neurol. 1987;27(2):120-129. ↗
  8. Schneider-Helmert D. The use of DSIP (delta sleep-inducing peptide) in the correction of phase-shifted insomnia. Dtsch Med Wochenschr. 1987;112(20):779-783. ↗
  9. Sudakov KV, et al.. The effect of delta sleep-inducing peptide on the EEG and power spectra in rat. Indian J Physiol Pharmacol. 2000;44(3):289-298. ↗
  10. Tobler I, Borbely AA. The effect of subcutaneous administration of delta sleep-inducing peptide (DSIP) on some parameters of sleep in the cat. Physiol Behav. 1987;39(2):245-248. ↗
  11. Schoenenberger GA. Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP). Eur Neurol. 1984;23(5):321-345. ↗
  12. Bjartell A, Castro MG, Ekman R, Sundler F, Widerlöv E, Loh YP. Immunoreactive delta sleep-inducing peptide secretion from mouse dissociated, anterior pituitary cells: regulation by corticotropin-releasing factor and arginine vasopressin. Neuroendocrinology. 1989;50:564-9. ↗
  13. Bjartell A, Ekman R, Hedenbro J, Sjölund K, Sundler F. Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones. Peptides. 1989;10:163-70. ↗
  14. Ahlman H, Ahlund L, Nilsson O, Dahlström A, Bjartell A, Ekman R. Coexistence of delta sleep-inducing peptide and serotonin in midgut carcinoid tumour cells in vivo and in vitro. International journal of cancer. 1989;44:641-7. ↗
  15. Lesch KP, Widerlöv E, Ekman R, Laux G, Schulte HM, Pfüller H, Beckmann H. Delta sleep-inducing peptide response to human corticotropin-releasing hormone (CRH) in major depressive disorder. Comparison with CRH-induced corticotropin and cortisol secretion. Biological psychiatry. 1988;24:162-72. ↗